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Controlled studies did not extend beyond 12 months Dosage regimens should be adjusted to individual patient needs and should continue for as long as clinically indicated.

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The use of H2-receptor antagonists has not been shown to be effective in altering the course of UGIB.

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We thank Karin Dearness, Managing Editor, Cochrane Upper Gastrointestinal and Pancreatic Diseases Group for providing administrative and logistical support for the conduct of the current review, and Racquel Simpson, Trials Search Co-ordinator, Cochrane Upper Gastrointestinal and Pancreatic Diseases Group for developing and executing the search strategies.

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Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order to decrease the risk of bleeding in people who have chronic idiopathic thrombocytopenic purpura (chronic ITP; an ongoing condition that may cause easy bruising or bleeding due to an abnormally low number of platelets in the blood).

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